P H A R M E K S Ltd. SCREENING COMPOUND DATABASES, May 2008 Thank you for your interest in screening compounds from PHARMEKS. COMPLETE database: phar08 - about 210 000 compounds UPDATE (from March 2007): phar08upd - about 25 000 compounds The compounds in the database PHARMEKS represent all of the compounds that can be supplied in quantities of 1mg, 2mg, 5mg, 10mg, up to 100mg in either vails or plate formats. The delivery timeline is 4-30 days depending on the size of the order. Compound structures in the DB, including charge distribution, zwitterions, tautomers etc. have been defined on the basis of quantum-chemical calculations, X-ray analysis, various physico-chemical analytical methods and they present to the maximum degree the actual electonic stuctures of multi-functional molecules. TECHNICAL SPECIFICATIONS --------------------------------------------- All databases included in the CD are formatted as MDL ISIS/Base 2.x DB files and SDF files. Field Descriptors in Databases/SD Files : id: Pharmeks Id structure/*structure: Structure Field stereo: Stereochemistry and other Comments price_category: Price Category logP: CLogP h_bond_donors: Number of H-Bond Donors h_bond_acceptors: Number of H-Bond Acceptors rot_bonds: Number of Rotatable Bonds supplier: PHARMEKS PRICING Price category: "A" - synthetic compounds "B" - semi-natural compounds "C" - natural compounds & unique derivatives PHARMEKS offers a flexible pricing model based on the number and sample quantity of compounds you require. There is no minimum order value. No royalties. No rights reserved by Pharmeks. QUALITY CONTROL: Only the highest quality products are supplied. NMR spectra are performed on Bruker 300-500 MHz spectrometers and/or Finnigan mass spectrometer. Purity level is 92-98%. For pricing, sales or other enquires, please contact: PHARMEKS Ltd., 10 A, Mironovskaya street Moscow 105318 Russia Tel/Fax: +7 (495) 702 9648 E-mail: sales@pharmeks.com WWW: www.pharmeks.com