June 2011 - about 260 000 compounds

May 2010 - over 251 000 compounds

August 2009 - about 228 500 compounds

May 2008 - about 210 000 compounds

March 2007 - over 185 000 compounds

May 2006 - over 165 000 compounds

November 2005 - over 130 000 compounds

March 2004 - over 105 000 compounds